Howell-Jolly bodies

These are basophilic nuclear remnants (fragments of chromatin/DNA) in RBCs. Mostly seen in post-splenectomy patients or those with asplenia. Commonly seen in adults with Sickle Cell disease (Hb SS) since these patients have undergone autosplenectomy by the time they reach their adulthood. Remember as opposed to "HEinz" bodies which start with "HE" and stands for HEmoglobin, Howell Jolly Bodies don't start with "HE" and are rather DNA or nuclear remnants.