MPN

A group of mature or maturing myeloid neoplasms that usually share the following features: Cytosis refers to the increase in various blood counts (red count, white count, platelet count) with the exception of Primary Myelofibrosis), splenomagly (less common in ET patients), and hypercellular marrow (except in Primary Myelofibrosis or spent phase of the some MPNs). The most common MPNs include CML, PV, ET, and Primary Myelofibrosis. CML has the t(9;22) translocation (BCR/ABL1) while PV, ET and Primary Myelofibrosis usually show the JAK2 mutation.