Blood/Blood Cells and Cellular Components ›› Platelets ›› Abnormal
Agranular Platelets
›Microscopic Features:
- Smaller than a normal RBC (usually much smaller, similar to normal platelets)
- Lacks the darker staining platelet granules
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: Rare to None
- BM: Rare to None
- LN: None
›May Resemble:
- Stain precipitate
- Malaria infection
- Babesia infection
›Differential Diagnoses:
Increased numbers may be see in:
Myeloid neoplasms (e.g. MDS, Acute leukemia or
Myeloproliferative Neoplasms)
Gray platelet syndrome (Alpha storage pool disease)
Myeloid neoplasms (e.g. MDS, Acute leukemia or
Myeloproliferative Neoplasms)
Gray platelet syndrome (Alpha storage pool disease)
›Classic Immunophenotype:
- CD41+
- CD61+
›Cartoon Image:
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›Misc:
Lack of platelet granules may be indicative of an underlying abnormality of the platelets such as but not limited to the inability of producing certain platelet granules.