Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Myeloid ›› Monocytes & Precursors ›› Abnormal
Histoplasmosis in Histiocytes
›Microscopic Features:
- Small round fungal forms seen within the cytoplasm of mature monocytes and histiocytes
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: None
- BM: None
- LN: None
›May Resemble:
- Leishmania in Histiocytes
- Cellular debris in Histiocytes
- Bacteria in Histiocytes
›Differential Diagnoses:
Histoplasmosis
Leishmaniasis
Cellular debris within histiocytes
Bacterial infection
Leishmaniasis
Cellular debris within histiocytes
Bacterial infection
›Classic Immunophenotype:
- N/A
›Cartoon Image:
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›Misc:
Histoplasma fungal forms lack kinetoplasts (small dark blue rod shaped structures within the organism) which are present in leishmania