Normal Lymph Node

‹ Back to Main Atlas

Secondary Lymphoid Tissues ›› Lymph Node ›› Normal

· hover the image to magnify

›Microscopic Features:

An encapsulated lymphoid tissue (as opposed to Mucosa Associated Lymphoid Tissue, also known as MALT)
Comprised of follicles (primary and secondary) and interfollicular areas
B-cells mostly reside in the follicles while T-cells mostly reside in between the follicles (interfollicular areas)
Most of the follicles are located within the cortex

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

PB: N/A
BM: N/A
LN: N/A

›May Resemble:

›Differential Diagnoses:

Reactive lymphoid hyperplasia
Infectious Lymphadenitis
Follicular Lymphoma

›Classic Immunophenotype:

"T"-cells have the "Tiny" CDs: CD2, CD3, CD4, CD5, CD7, CD8
"B"-cells have the "Bigger" CDs: CD19, CD20, CD22

›Cartoon Image:

›Misc:

In a normal lymph, the primary follicles (not antigen stimulated and no germinal center) and secondary follicles (antigen stimulated with a germinal center) are where most B-cell reside
The interfollicular (between follicles) areas are where most T-cells reside
In summary: B-cells mostly reside in the follicles while T-cells mostly reside in between the follicles (interfollicular areas)