ALCL

Also known as Anaplastic Large Cell Lymphoma is usually an aggressive mature/maturing T-cell lymphoma that typically involve nodal tissue (e.g. lymph nodes) and sometimes skin (Cutaneous ALCL has better prognosis). The nodal ALCLs can be either ALK (Anaplastic Large cell Kinase) positive (better prognosis and a potential source of therapy) or ALK negative (worse prognosis in nodal ALCLs). Please note that the cutaneous ALCL is typically ALK negative with best prognosis. In Summary: Amongst ALCLs, ALK negative cutaneous ALCL has the best prognosis while the Nodal ALK negative ALCL has the worst prognosis.