Coumadin

Generic name: Warfarin is an anticoagulant that acts by inhibiting the vitamin K-dependent synthesis of factors II, VII, IX, and X, as well as proteins C & S. Used in the prevention of thrombosis and clinical settings such as atrial fibrillation, the presence of artificial heart valves, deep venous thrombosis, and pulmonary embolism. Degree of anticoagulation is monitored by INR. Coumadin is contraindicated in pregnancy. Adverse effects include hemorrhage, warfarin necrosis, and osteoporosis. Effects of Coumadin can be reversed by giving vitamin K. Fresh-frozen plasma (FFP) can be given when rapid reversal is needed.