Hematogones

Early B-cells in the developmental stage following precursor B-cells and before small naïve B-cell found in the bone marrow. Hematogones are more abundant in normal infant marrow and less common in normal adult marrow. A normal hematogone population shows a range of morphology and immunophenotype reflecting a spectrum of maturation. The typical morphology of hematogones is CD19+ and CD10+ with variable expression of CD34, TdT and CD20 depending on their maturation stage. They typically do not express Kappa or Lambda light chains.(Early Hematogones)(Late Hematogones)