Macrocytic

Usually refers to Macrocytic (larger) RBCs as seen in macrocytic anemias. Characterized by an elevated MCV (larger RBCs with MCV >100fL). On blood smears, macrocytic red cells are larger than a lymphocyte nucleus. Common causes include B12 or Folate deficiency, Liver disease, increased reticulocytes, drug-induced (e.g. methotrexate), and MDS.