Myeloproliferative neoplasms

A group of mature or maturing myeloid neoplasms that usually share the following features: Cytosis (increase in a cell line in blood with the exception of Primary Myelofibrosis), Splenomagly (less common in ET patients), and Hypercellular marrow (except in Primary Myelofibrosis or spent phase of the some MPNs). The most common MPNs include CML, PV, ET, and Primary Myelofibrosis. CML has the t(9;22) translocation (BCR/ABL1) while PV, ET and Primary Myelofibrosis many show the JAK2 mutation.