Pelger-Huet anomaly

An rare inherited condition due to lamin B receptor mutation in which most of the peripheral blood neutrophils present with bilobed nuclei connected with a thin filament of chromatin (similar to the bilobed nuclei noted on normal mature eosinophils but without the eosinophilic granules). In heterozygous individuals these neutrophils appear to maintain their function, and most of these individuals are asymptomatic (hence the term anomaly rather than disease).