Plasma cell

This is a terminally differentiated B-cell that produces and secretes immunoglobulins (antibodies). Some B-cells in the peripheral lymphoid tissues (e.g. lymph node) further differentiate and become plasma cells. Normally plasma cells are not present in the peripheral blood and reside in secondary lymphoid tissues and other tissues such as the bone marrow. It has an eccentric nucleus with a "clock-face" chromatin pattern and abundant blue cytoplasm and a perinuclear clearing.