IFE

Immunofixation Electrophoresis is an antibody-based method to detect and characterize clonal M-spikes noted on SPEP in patients with suspected plasma cell or B-cell neoplasms. This method reveals the M-spike as clonal with IgG, IgA, or IgM (rarely IgE or IgD) molecules that are either kappa or lambda light chain-restricted. (AKA a clonal antibody from a clonal neoplastic process such as a plasma cell neoplasm or a B-cell lymphoma). Note: IgG and IgA clones are typically associated with a plasma cell neoplasm (e.g. plasma cell myeloma or MGUS, etc.) while IgM clones may be related to Waldenstrom Macroglobulinemia which is typically associated with lymphoplasmacytic lymphoma.