Thrombotic Thrombocytopenic Purpura

Also known as TTP is a microangiopathic hemolytic anemia that is typically due to deficiency of ADAMTS-13 (a metalloprotease responsible for cleavage of large multimers of vW factor). Similar to HUS remember the mnemonic "Brain FART" (complements of Dr. M. Baughn) which is "Brain" for the neurologic problems (more commonly associated with TTP than HUS), F for Fever, A for Anemia, R for Renal failure (more commonly associated with HUS than TTP), and T for the Thrombocytopenia.