H. H. Rashidi, MD
J. C. Nguyen, MD
HematologyOutlines.com

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Blood/Blood Cells and Cellular Components ›› Red Blood Cells ›› Abnormal

Stomatocyte

Stomatocyte
Stomatocyte
Stomatocyte

›Microscopic Features:

  • About the same size as a normal RBC
  • Slit-like or mouth-like central pallor (Hence the term stoma)

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

  • PB: Rare to None
  • BM: Rare to None
  • LN: Rare to None

›May Resemble:

›Differential Diagnoses:

Increased in:
Hereditary stomatocytosis
Liver disease
Tangier disease
Rh null disease
Artifact

›Classic Immunophenotype:

  • N/A

›Cartoon Image:

Stomatocyte cartoon
Click and dragRed blood cell for scalefor direct comparison

›Misc:

Similar to Hereditary Spherocytosis, Hereditary Stomatocytosis is also due to an underlying RBC membrane defect