Blood/Blood Cells and Cellular Components ›› Platelets ›› Abnormal
Giant Platelets
›Microscopic Features:
- Larger than normal RBC
- Usually looks like a very large platelet and has platelet granules in the cytoplasm
- It may be confused sometimes for a lymphocyte
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: None
- BM: None
- LN: None
›May Resemble:
›Differential Diagnoses:
Increased numbers may be see in:
Myeloid neoplasms (e.g. MDS, Acute leukemia or
Myeloproliferative Neoplasms)
Post-splenectomy patients
Leukemoid reaction
Some rare inherited conditions (e.g.May-Hegglin anomaly, Bernard-Soulier syndrome, etc.)
Myeloid neoplasms (e.g. MDS, Acute leukemia or
Myeloproliferative Neoplasms)
Post-splenectomy patients
Leukemoid reaction
Some rare inherited conditions (e.g.May-Hegglin anomaly, Bernard-Soulier syndrome, etc.)
›Classic Immunophenotype:
- CD41+
- CD42+
- CD61+
›Cartoon Image:
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›Misc:
The term giant platelet is used if size is greater that that of a normal RBC