Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Myeloid ›› Granulocytes & Precursors ›› Normal
Band
›Microscopic Features:
- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic ratio (cytoplasm is relatively increased)
- Kidney bean-shaped Nucleus with nucleus indentation (Greater than 1/2 the diameter of the nucleus is indented) and mature chromatin (clumped)
- Nucleoli are absent
- More cytoplasm with only secondary granules
- Secondary (specific) granules of neutrophilic (lilac), eosinophilic (red-orange), or basophilic (blue) color are present based on precursor type
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: Rare scattered (~1-5%)
- BM: Scattered (~10-15%)
- LN: Rare to None
›May Resemble:
›Differential Diagnoses:
Increased in:
Infections (especially bacterial)
Myeloproliferative disorders (e.g. CML)
Leukemoid reaction due to stress, etc.
Post-GCSF therapy
Infections (especially bacterial)
Myeloproliferative disorders (e.g. CML)
Leukemoid reaction due to stress, etc.
Post-GCSF therapy
›Classic Immunophenotype:
- CD34-
- CD117-
- HLA-DR-
- CD13+
- CD33+
- CD15+
- CD11b+
- CD16+
›Cartoon Image:
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3D Representation
›Misc:
When Bandemia (increased bands in blood) is noted, an underlying infection (specially bacterial) needs to be ruled out