H. H. Rashidi, MD
J. C. Nguyen, MD
HematologyOutlines.com

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Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Myeloid ›› Megakaryocytes & Precursors ›› Abnormal

Micro-Megakaryocyte

Micro-Megakaryocyte
Micro-Megakaryocyte
Micro-Megakaryocyte

›Microscopic Features:

  • 3-6x larger than a mature RBC
  • Lower nuclear to cytoplasmic ratio because of increased cytoplasm
  • Many are hypolobated (1-2 lobes) with a mature (clumped chromatin) nucleus
  • Nucleoli are absent
  • Cytoplasm is abundant and light blue and usually lacks granules

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

  • PB: None
  • BM: None
  • LN: None

›May Resemble:

›Differential Diagnoses:

Usually sssociated with:
MDS
Post Chemotherapy
Etc.

›Classic Immunophenotype:

  • CD41+
  • CD42+
  • CD61+

›Cartoon Image:

Micro-Megakaryocyte cartoon
Click and dragRed blood cell for scalefor direct comparison

›Misc:

May be associated with a myelodysplastic syndrome (MDS)