Sezary syndrome

Sezary syndrome is defined as a constellation of 1) erythroderma (with involvement by a cutaneous T-cell lymphoma which is usually comprised of CD4(+) T-cells), 2) circulating abnormal T-cells in the blood (sezary cells) and 3) lymphadenopathy. On peripheral blood smear these Sezary cells are the abnormal lymphocytes with nuclear membrane irregularities and scant cytoplasm. When compared to the most common cutaneous T-cell lymphoma (mycoses_fungoides), sezary syndrome patients have a much worse prognosis.