H. H. Rashidi, MD
J. C. Nguyen, MD
HematologyOutlines.com

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Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

May Hegglin Anomaly

May Hegglin Anomaly
May Hegglin Anomaly
May Hegglin Anomaly

›Microscopic Features:

  • Characterized by neutrophils with prominent Dohle-like bodies and background Giant platelets
  • The Dohle-like bodies are half the diameter of an RBC with light blue crescent shaped appearance
  • Besides the neutrophils, other granulocytes, monocytes, and lymphocytes may also be involved

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

  • PB: None
  • BM: None
  • LN: None

›May Resemble:

›Differential Diagnoses:

May Hegglin Anomaly
Infection associated

›Classic Immunophenotype:

  • CD45+
  • High SCC
  • CD10+
  • CD11b+
  • CD13+
  • CD16+

›Cartoon Image:

May Hegglin Anomaly cartoon
Click and dragRed blood cell for scalefor direct comparison

›Misc:

Associated with mutation in MYH-9 (Myosin Heavy Chain gene)
May Hegglin: Neutrophil with Dohle-like body & background Giant Platelets