Chediak Higashi Neutrophils

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Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

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›Microscopic Features:

Abnormal cytoplasmic inclusions invlolving the white blood cells (neutrophils, monocytes, eosinophils and lymphocytes)
Variably sized large aggregates of purple/blue/red granules

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

PB: None
BM: None
LN: None

›May Resemble:

Eosinophil
Segmented Neutrophil
Band Neutrophil
Neutrophil with toxic granules
Basophil

›Differential Diagnoses:

Chediak Higashi syndrome

›Classic Immunophenotype:

›Cartoon Image:

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›Misc:

Chediak Higashi syndrome: Caused from abnormal fusion of primary granules which results in a malfunctioning WBC with a diminished phagocytic capability. The syndrome is characterized by Pancytopenia, Neuropathy, Oculocuteneous Albinism, hepatosplenomegaly, lymphadenopathy, and recurrent infections.