Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal
Neutrophil with toxic granules
›Microscopic Features:
- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
- Nucleus is mature and divided into 3 to 5 lobes connected by thin chromatin filaments
- Nucleoli are absent
- Darker (red/purple) granules are easily noted (similar to the primary granules noted in promyelocytes)
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: Rare to None
- BM: Rare to None
- LN: None
›May Resemble:
- Mature Segmented Neutrophil
- HyperSegmented Neutrophil
- Pseudo-Pelger Huet Neutrophil
- Band Neutrophil
- Large Granular Lymphocyte
- Metamyelocyte
- Myelocyte
- Promyelocyte
- Monocyte
›Differential Diagnoses:
Usually associated with:
Infection
Inflammatory conditions
Infection
Inflammatory conditions
›Classic Immunophenotype:
- CD45+
- High SCC
- CD10+
- CD11b+
- CD13+
- CD16+
›Cartoon Image:
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for direct comparison
for direct comparison
›Misc:
Usually associated with an underlying infection
Neutrophils in infectious processes may also show vacuoles
Neutrophils in infectious processes may also show vacuoles