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Blood/Blood Cells and Cellular Components ›› Neutrophils ›› Abnormal

Hypersegmented Neutrophil

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Hypersegmented Neutrophil

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Additional Image 1

Additional Image 1: Hypersegmented Neutrophil

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›Microscopic Features:

• 3x larger than a mature RBC
• Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
• Nucleus is mature and has >5 lobes connected by thin chromatin filaments
• Nucleoli are absent
• More cytoplasm with only secondary granules
• Secondary (specific) granules are neutrophilic (lilac)

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: None
• BM: None
• LN: None

›May Resemble:

• Mature Segmented Neutrophil[Compare]
• Pseudo-Pelger Huet Neutrophil[Compare]
• Band Neutrophil[Compare]
• Neutrophil with toxic granules[Compare]
• Metamyelocyte[Compare]
• Myelocyte[Compare]
• Promyelocyte[Compare]
• Monocyte[Compare]

›Differential Diagnoses:

›Classic Immunophenotype:

• CD45+
• High SCC
• CD10+
• CD11b+
• CD13+
• CD16+

›Cartoon Image:

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›Misc: