Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Myeloid ›› Granulocytes & Precursors ›› Abnormal
Pseudo Pelger Huet Neutrophil
›Microscopic Features:
- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
- Nucleus is mature with 2 lobes connected by thin chromatin filament. The granules are neutrophilic (pink)
- Nucleoli are absent
- In some cases, hypergranulation, hypogranulation, or abnormal granules can be seen
- Pseudo Pelger-Huet neutrophils are a form of dysplastic neutrophils
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: Rare to None
- BM: Rare to None
- LN: None
›May Resemble:
›Differential Diagnoses:
Associated with:
Myelodysplastic Syndrome (MDS)
Pelger Huet Anamoly (if they are true pelger huet cells)
Myelodysplastic Syndrome (MDS)
Pelger Huet Anamoly (if they are true pelger huet cells)
›Classic Immunophenotype:
- CD45+
- Lowered SCC
- CD10+/-
- CD11b+/-
- CD13+/-
- CD16+/-
›Cartoon Image:
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for direct comparison
for direct comparison
›Misc:
Normal segmentation is 3-5 lobes while Hyposegmentation is <3 lobes and Hypersegmentation is >5 lobes
The immunoprofile may be aberrant if it's dysplastic and associated with MDS
The immunoprofile may be aberrant if it's dysplastic and associated with MDS