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Blood/Blood Cells and Cellular Components ›› Lymphocytes ›› Abnormal

Large Granular Lymphocyte (LGL)

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Large Granular Lymphocyte (LGL)

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Additional Image 1

Additional Image 1: Large Granular Lymphocyte (LGL)

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Additional Image 2: Large Granular Lymphocyte (LGL)

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Additional Image 3

Additional Image 3: Large Granular Lymphocyte (LGL)

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›Microscopic Features:

• 2-4x larger than a mature RBC
• Low nuclear to cytoplasmic ratio because of the increased cytoplasm
• Round-to-convoluted nuclear border with mature chromatin (clumped chromatin)
• Nucleoli are absent
• Cytoplasm is abundant, light blue
• Pink/red granules in the cytoplasm (hence the term "granular")

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

• PB: Rare to None
• BM: None
• LN: None

›May Resemble:

• Reactive lymphocyte[Compare]
• Monocyte[Compare]
• Promyelocyte[Compare]

›Differential Diagnoses:

›Classic Immunophenotype:

• CD2+
• CD3+
• CD4-
• CD8+
• CD5+
• CD7+
• CD56+

›Cartoon Image:

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›Misc: