Blood/Blood Cells and Cellular Components ›› Lymphocytes ›› Abnormal
Reactive Lymphocyte
›Microscopic Features:
- 2-4x larger than a mature RBC
- Increased amount of light blue cytoplasm
- Nucleoli usually absent
- Cytoplasm is usually indented by surrounding RBCs
- Granules are usually absent (as opposed to LGL)
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: Rare to none
- BM: None
- LN: None
›May Resemble:
›Differential Diagnoses:
Increased numbers in blood may be associated with:
Epstein-Barr virus infection (Infectious mononucleosis)
CMV infection
Other viral Infections
Drug reaction
Chronic inflammatory disorders (e.g.systemic lupus erythematosis, rheumatoid arthritis)
Epstein-Barr virus infection (Infectious mononucleosis)
CMV infection
Other viral Infections
Drug reaction
Chronic inflammatory disorders (e.g.systemic lupus erythematosis, rheumatoid arthritis)
›Classic Immunophenotype:
- CD2+
- CD3+
- CD8+
- CD4-
- CD5+
- CD7+
›Cartoon Image:
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›Misc:
Increased numbers may be seen in some viral infections (e.g. EBV mononucleosis)