H. H. Rashidi, MD
J. C. Nguyen, MD
HematologyOutlines.com

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Blood/Blood Cells and Cellular Components ›› Lymphocytes ›› Normal

Lymphocyte-Normal

Lymphocyte-Normal
Lymphocyte-Normal
Lymphocyte-Normal

›Microscopic Features:

  • Slightly (1.5x) larger than a mature RBC
  • High nuclear to cytoplasmic ratio but with
  • Round mature Nucleus (clumped chromatin)
  • Nucleoli are absent
  • Cytoplasm is scant, light blue and lacks granules

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

  • PB: Many (second most common WBC component of blood)
  • BM: Scattered
  • LN: B-cells mainly in follicular areas and T-cells mainly in Interfollicular areas

›May Resemble:

›Differential Diagnoses:

Increased number of normal (non-neoplastic) lymphocytes may be associated with:
Infection (Viral, fungal, and some bacterial)
Autoimmune disorders

›Classic Immunophenotype:

  • N/A

›Cartoon Image:

Lymphocyte-Normal cartoon
Click and dragRed blood cell for scalefor direct comparison

›Misc:

Normal lymphocytes are the second most common WBCs in the blood (after neutrophils)