H. H. Rashidi, MD
J. C. Nguyen, MD
HematologyOutlines.com

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Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Myeloid ›› Granulocytes & Precursors ›› Eosinophilic ›› Abnormal

Dysplastic Eosinophil

Dysplastic Eosinophil
Dysplastic Eosinophil
Dysplastic Eosinophil
Additional Image 1: Dysplastic Eosinophil
Additional image 1: Dysplastic Eosinophil

›Microscopic Features:

  • 2-3x larger than a mature RBC
  • Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
  • Nucleus is mature and usually with 2 lobes connected by thin chromatin filament (some have 1 lobe or more than 2 lobes)
  • Nucleoli are usually absent
  • More cytoplasm with Abnormal secondary granules (usually darker in color resembling basophilic granules)
  • The granules are heterogenous and vacuoules may occasionally be noted as well

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

  • PB: None
  • BM: None
  • LN: None

›May Resemble:

›Differential Diagnoses:

Associated with:
Certain AMLs such as AML with Inv 16 or t(16;16)
Certain Myeloproliferative neoplasms
Certain Myelodysplastic Syndromes

›Classic Immunophenotype:

  • CD45dim+
  • High SSC (Side light scatter)
  • CD13dim+
  • CD16-
  • CD15dim+
  • (May have some immunophenotypic variability compared to normal eosinophils)

›Cartoon Image:

Dysplastic Eosinophil cartoon
Click and dragRed blood cell for scalefor direct comparison

›Misc:

AML with inv16 or t(16;16) was also known as AML-M4Eo (which stood for an AML with monocytic differentiation and Abnormal Eosinophils)