Hodgkin lymphoma

An indolent B-cell lymphoma that usually presents in supradiaphragmatic areas (above the diaphragm such as supraclavicular lymph nodes or Anterior Mediastinum). There is a bimodal age distribution (most patients present in their 20s and 50s). Four main subtypes are: Nodular Sclerosis, Mixed Cellularity, Lymphocyte-rich, and Lymphocyte-depleted. The hallmark of all Classical Hodgkin lymphomas is the Reed-Sternberg cell (RS cell) which usually have the following immunophenotype: dim PAX5+, CD30+, CD15+, CD20-, OCT2- and BOB1-.