Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Myeloid ›› Granulocytes & Precursors ›› Abnormal
Hypogranular or Agranular Neutrophil
›Microscopic Features:
- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic ratio (more cytoplasm than nucleus)
- Nucleus is mature
- Nucleoli are absent
- Lack or diminished neutrophilic granules
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: Rare to None
- BM: Rare to None
- LN: None
›May Resemble:
›Differential Diagnoses:
Increased in:
Myelodysplastic Syndrome
Staining artifact giving rise to pseudo-hypogranularity
Myelodysplastic Syndrome
Staining artifact giving rise to pseudo-hypogranularity
›Classic Immunophenotype:
- CD45+
- Lowered SCC
- CD10+/-
- CD11b+/-
- CD13+/-
- CD16+/-
›Cartoon Image:
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for direct comparison
for direct comparison
›Misc:
The low SCC noted in flow cytometry is due to the hypogranularity.
The immunoprofile may be aberrant if it's dysplastic and associated with MDS
The immunoprofile may be aberrant if it's dysplastic and associated with MDS