Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Myeloid ›› Granulocytes & Precursors ›› Abnormal
Dysplastic Eosinophil
›Microscopic Features:
- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic (N/C) ratio (more cytoplasm than nucleus)
- Nucleus is mature and usually with 2 lobes connected by thin chromatin filament (some have 1 lobe or more than 2 lobes)
- Nucleoli are usually absent
- More cytoplasm with Abnormal secondary granules (usually darker in color resembling basophilic granules). The granules are usually heterogenous and sometimes vacuoles may also be noted.
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: None
- BM: None
- LN: None
›May Resemble:
- Eosinophil
- Basophil
- Neutrophil (mature)
- Pseudo-Pelger Huet Neutrophil
- Band Neutrophil
- Neutrophil with toxic granules
›Differential Diagnoses:
Associated with:
Certain AMLs such as AML with Inv 16 or t(16;16)
Certain Myeloid disorders/neoplasms
Artifact of staining must be ruled out
Certain AMLs such as AML with Inv 16 or t(16;16)
Certain Myeloid disorders/neoplasms
Artifact of staining must be ruled out
›Classic Immunophenotype:
- N/A
›Cartoon Image:
Click and drag
for direct comparison
for direct comparison
›Misc:
May be associated with certain myeloid neoplasms such as AML with invresion 16 or t(16;16)