Primary Hematopoietic and Lymphoid Tissue ›› Bone Marrow ›› Myeloid ›› Granulocytes & Precursors ›› Eosinophilic ›› Normal
Eosinophilic Precursor
›Microscopic Features:
- 2-3x larger than a mature RBC
- Low nuclear to cytoplasmic (N/C) ratio (more cytoplasm than nucleus)
- Nucleus is mature and usually with 1 lobe
- Nucleoli may be present depending on stage of maturation
- Secondary (specific) granules are eosinophilic (red-orange) in Myelocyte to mature eosinophil stage
›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:
- PB: None
- BM: 1-2%
- LN: None
›May Resemble:
- Mature Eosinophil
- Neutrophilic Myelocyte
- Neutrophilic Metamyelocyte
- Segmented Neutrophil
- Pseudo-Pelger Huet Neutrophil
- Band Neutrophil
- Neutrophil with toxic granules
- Promyelocyte
- Basophil
›Differential Diagnoses:
Increased in:
Myeloproliferative neoplasms (some)
Allergy-related (e.g. Asthma): In bone marrow
Drug reactions: In bone marrow
Invasive parasitic infections: In bone marrow
AML (rare variants)
Myeloproliferative neoplasms (some)
Allergy-related (e.g. Asthma): In bone marrow
Drug reactions: In bone marrow
Invasive parasitic infections: In bone marrow
AML (rare variants)
›Classic Immunophenotype:
- CD45dim+
- High SSC (Side light scatter)
- CD13dim+
- CD16-
- CD15dim+
- (May have some immunophenotypic variability compared to mature eosinophils based on the stage of maturation of the precursor)
›Cartoon Image:
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›Misc:
Hypolobation is due to its immaturity.