Diffuse Large B-cell Lymphoma

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Secondary Lymphoid Tissues ›› Lymph Node ›› Neoplastic: Non-Hodgkin Lymphoma

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›Microscopic Features:

Sheets or clusters of large (>2.5x the size of a mature lymphocyte or equal or > than the size of a histiocyte) abnormal lymphocytes involving lymph node or other tissue
As the name suggests, the abnormal lymphocytes diffusely infiltrate the involved tissue (typically lacks a nodular/follicular pattern of growth)

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

PB: N/A
BM: N/A
LN: N/A

›May Resemble:

›Differential Diagnoses:

Mantle cell lymphoma (blastoid variant)
Follicular lymphoma (high grade, e.g. 3B)
Burkitt Lymphoma
Small Lymphocytic Lymphoma (SLL: The CLL equavalent in tissue)
Mantle Cell Lymphoma
Non-neoplastic reactive Lymph node
Hodgkin Lymphoma

›Classic Immunophenotype:

CD19+
CD20+
CD10+ (Germinal center phenotype)
CD10-/BCL6-/MUM1+ (Non-Germinal Center phenotype)

›Misc:

Germinal center phenotype (CD10+) has better prognosis (usually responds better to R-CHOP chemotherapy treatment)
Many have variable morphology (some with prominent nucleoli, some with high mitotic rate, etc.) and many present as mass lesions