Burkitt Lymphoma

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Secondary Lymphoid Tissues ›› Lymph Node ›› Neoplastic: Non-Hodgkin Lymphoma

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›Microscopic Features:

"Starry Sky" pattern due to many background apoptotic cells
The lymph node is usually effaced (closed subcapsular sinus and loss of follicle architecture)
The normal lymphoid tissue is replaced by a diffuse lymphoid proliferation of intermediate sized lymphocytes with a very high mitotic rate

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

PB: N/A
BM: N/A
LN: N/A

›May Resemble:

›Differential Diagnoses:

Non-neoplastic reactive Lymph node
Small Lymphocytic Lymphoma (SLL: The CLL equavalent in tissue)
Mantle Cell Lymphoma
Diffuse Large B-cell Lymphoma
Follicular Lymphoma

›Classic Immunophenotype:

CD19+
CD20+
CD10+
BCL2-
CD5-
Ki67 proliferation index is nearly 100%

›Cartoon Image:

›Misc:

Associated with t(8;14) c-MYC;IgH genes
Less commonly associated with other translocations including the light chains (kappa or lambda): t(2:8) or t(8;22)