T-cell Lymphoma: ALK+ Anaplastic Large Cell Lymphoma

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Secondary Lymphoid Tissues ›› Lymph Node ›› Neoplastic: Non-Hodgkin Lymphoma

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›Microscopic Features:

Sheets or clusters of Large (>2.5x the size of a mature lymphocyte or equal or > than the size of a histiocyte) abnormal lymphocytes usually involving lymph node but may involve other tissue
Anaplastic Large Cell Lymphoma (ALCL) ususally have horse-shoe shaped large abnormal cells known as "hallmark cells"
ALCL typically involves the lymph node sinuses but it may have a diffuse pattern of growth as well

›Normal % blood-PB, marrow-BM, lymphoid tissue-LN:

PB: N/A
BM: N/A
LN: N/A

›May Resemble:

›Differential Diagnoses:

Diffuse Large B-cell Lymphoma
Mantle cell lymphoma (blastoid variant)
Follicular lymphoma (high grade, e.g. 3B)
Burkitt Lymphoma
Small Lymphocytic Lymphoma (SLL: The CLL equivalent in tissue)
Mantle Cell Lymphoma
Non-neoplastic reactive Lymph node
Hodgkin Lymphoma

›Classic Immunophenotype:

CD3+
CD30+
ALK+
CD19-
CD20-

›Misc:

Most are associated with the t(2;5) ALK1-NPM translocation